Dr. Kaveh Daneshvar is a cell and molecular biologist who studies the role of regulatory RNAs in mammalian gene regulation. He offers expertise in RNA biology, stem cell biology, functional genomics, genome editing, and computational biology to reveal the genetic and biochemical basis of diseases. Kaveh is an efficient communicator with several high-impact publications and oral presentations. Experienced leader of teams of biomedical researchers and innovators in conducting projects in fast-paced environments.
Well-versed in the culture and manipulation of human pluripotent stem cells (hESCs and IPSCs).
Discovered a novel non-coding RNA and an enhancer that regulates the differentiation of human pluripotent stem cells.
Differentiation of pluripotent stem cells to embryonic and liver lineages for disease modeling, drug screening, and regenerative medicine.
Generation of iPSC cells via Reprogramming of Somatic Cells by RNA vectors.
Phase-separated RNA-protein aggregates in transcriptional activation.
Developed "CUT&RUNER" for the identification of RNA-chromatin interaction.
Identification of RNA-protein interaction by RNA-centric (RAP and ChIRP) and protein-centric (RIP and CLIP) approaches.
Experience in NGS bioinformatics toolsets in the command line environment.
Fluent in R programming for the analysis of biological data (Bioconductor), statistical analysis, and data visualization.
Complete analysis of next-generation sequencing data (ChIP-seq and RNA-seq): sequence alignment, differential transcriptome analysis, and peak calling.
Design and execution of CRISPR/Cas9 experiments in human and murine cells.
Experienced in the use of CRISPRi (KRAB domain) and CRISPRa (VPR) for gene activation and silencing.
Gene silencing by antisense oligos, siRNAs, and lentiviral vectors.
Gene delivery by lentiviral vectors and transposase systems.